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CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015)

modeldb.science/184139

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
E807.hoc		E807.hoc
Exp2GluSyn.mod		Exp2GluSyn.mod
Fig7Bb_(IK_conditioned).hoc		Fig7Bb_(IK_conditioned).hoc
Fig7Bb_(IK_control).hoc		Fig7Bb_(IK_control).hoc
Fig7Bc(Gin).hoc		Fig7Bc(Gin).hoc
Fig7C_(AC-EPSP).hoc		Fig7C_(AC-EPSP).hoc
Fig7C_(MF-EPSP).hoc		Fig7C_(MF-EPSP).hoc
Fig7C_(PP-EPSP).hoc		Fig7C_(PP-EPSP).hoc
Fig7D_(AC-EPSP).hoc		Fig7D_(AC-EPSP).hoc
Fig7D_(MF-EPSP).hoc		Fig7D_(MF-EPSP).hoc
Fig7D_(PP-EPSP).hoc		Fig7D_(PP-EPSP).hoc
Fig7E_(control).hoc		Fig7E_(control).hoc
Fig7E_(lowGkd).hoc		Fig7E_(lowGkd).hoc
Fig7E_(lowGkdlowGna).hoc		Fig7E_(lowGkdlowGna).hoc
KaProx.mod		KaProx.mod
KdBG40.mod		KdBG40.mod
Kdr.mod		Kdr.mod
KhdM01.mod		KhdM01.mod
L22.hoc		L22.hoc
Na.mod		Na.mod
ReadMe.html		ReadMe.html
fixnseg.hoc		fixnseg.hoc
mosinit.hoc		mosinit.hoc
screenshot.png		screenshot.png

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<html><pre>
This model simulates the contribution of dendritic Na+ and D-type K+
channels to EPSPs at three different locations of apical dendrites,
which mimicking innervation sites of mossy fibers (MF), recurrent
fibers (AC), and perforant pathway (PP).

The model files are associated with the figure 7 of the paper:

Jung Ho Hyun, Kisang Eom, Kyu-Hee Lee, Jin Young Bae, Yong Chul Bae,
Myoung-Hwan Kim, Sooyun Kim, Won-Kyung Ho and Suk-Ho Lee (2015) Kv1.2
mediates heterosynaptic modulation of direct cortical synaptic inputs
in CA3 pyramidal cells. J. Physiol. 593(16): 3617-3643.

In this paper, we investigated the cellular mechanisms underlying
MF-induced heterosynaptic long-term potentiation of perforant path
(PP) inputs to CA3 pyramidal cells. We showed that this heterosynaptic
potentiation is mediated by downregulation of Kv1.2 channels, which
comprises D-type K current. The downregulation of Kv1.2 preferentially
enhanced PP-evoked EPSPs which occur at distal apical dendrites. Such
enhancement of PP-EPSPs required activation of dendritic Na+ channels,
and its threshold was lowered by downregulation of Kv1.2.

You can reproduce each panel in Fig 7 of the paper by running
corresponing hoc file, after compiling the mod files. You can also start
with the mosinit.hoc (with nrngui) and click one of the buttons. See
<a href="http://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html">http://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.html</a> for more
help downloading and running models.

Note that the color codes for traces of Fig7C-E (for example the MF in
7Da):
<img src="./screenshot.png" alt="screenshot" width="550">
are as follows:
1) blue, EPSPs at the soma
2) red, EPSPs at an apical dendrite of stratum radiatum (AC synaptic
site)
3) green, EPSPs at an apical dendrite of stratum lacunosum moleculare
(PP synaptic site)

In Fig7C*.hoc and Fig7D*.hoc, EPSPs will be simlulated under the
conditions of following order:
1) control
2) low Gkd (10% of control)
3) low Gkd & low dendritic Na channel (50%)
4) Normal Gkd & low dendritic Na channel
</pre></html>