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raufs authored Jul 6, 2024
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[![Anaconda-Server Badge](https://anaconda.org/bioconda/skder/badges/platforms.svg)](https://anaconda.org/bioconda/skder)
[![Anaconda-Server Badge](https://anaconda.org/bioconda/skder/badges/license.svg)](https://anaconda.org/bioconda/skder)

skDER: efficient & high-resolution dereplication of microbial genomes to select representatives for comparative genomics and metagenomics.
skDER (& CIDDER): efficient & high-resolution dereplication of microbial genomes to select representatives for comparative genomics and metagenomics.

> ***Note:*** Please make sure to use version 1.0.7 or greater to avoid a bug in previous versions!
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#### CiDDER

In v1.2.0, we also introduced a second program called CiDDER (CD-hit based DEReplication) - which allows for optimizing selection of a minimal number of genomes that achieve some level of saturation of the pan-genome of the full set of genomes (see below for details).
In v1.2.0, we also introduced a second program called CiDDER (CD-hit based DEReplication) - which allows for optimizing selection of a minimal number of genomes that achieve some level of saturation of the pan-genome of the full set of genomes (see below for details). Note, CD-HIT determines protein clusters, not proper ortholog groups, and as such an approximation is made of the pan-genome space being sampled by representative genomes.

## Details on Dereplication Algorithms

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instead of performing a copy of the files.
-c CPUS, --cpus CPUS Number of CPUs to use [Default is 1].
-m MEMORY, --memory MEMORY
The memory limit for CD-HIT in Gigabytes [Default is 4].
The memory limit for CD-HIT in Gigabytes [Default is 0 = unlimited].
-u, --ncbi_nlm_url Try using the NCBI ftp address with '.nlm' for
ncbi-genome-download if there are issues.
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