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mutant_checker_table_fix.txt
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mutant_checker_table_fix.txt
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# REMOVE # 6 LC13 HLA-B*08:01 HLA-B*08:01 WT nan D30A >200 \N \N \N \N \N 298.15 FLRGRAYGL WT \N \N \N \N 1MI5 \N A CDR1 TISGTDY D 15640805 Biacore 3000 CM5 FLRGRAYGL-HLA-B*08:01 direct LC13 D30A
166 Hy.1B11 HLA-DQA1*01:02 | HLA-DQB1*05:01 HLA-DQA1*01:02 | HLA-DQB1*05:01 WT nan Y48A 15.8 +/- 0.9 \N \N 0.91 -6.55 0.06 298.15 ENPVVHFFKNIVTPR WT \N \N \N \N 3PL6 \N B CDR2 FQGTGA E 21199956 Biacore 3000 CM5 ENPVVHFFKNIVTPR-HLA-DQA1*01:02 | HLA-DQB1*05:01 indirect Hy.1B11 Y46a
167 Hy.1B11 HLA-DQA1*01:02 | HLA-DQB1*05:01 HLA-DQA1*01:02 | HLA-DQB1*05:01 WT nan Q50A 108 +/- 4 \N \N 0.13 -5.41 1.21 298.15 ENPVVHFFKNIVTPR WT \N \N \N \N 3PL6 \N B CDR2 FQGTGA E 21199956 Biacore 3000 CM5 ENPVVHFFKNIVTPR-HLA-DQA1*01:02 | HLA-DQB1*05:01 indirect Hy.1B11 Q48A
168 Hy.1B11 HLA-DQA1*01:02 | HLA-DQB1*05:01 HLA-DQA1*01:02 | HLA-DQB1*05:01 WT nan T52A 20 +/- 1.2 \N \N 0.72 -6.41 0.19 298.15 ENPVVHFFKNIVTPR WT \N \N \N \N 3PL6 \N B CDR2 FQGTGA E 21199956 Biacore 3000 CM5 ENPVVHFFKNIVTPR-HLA-DQA1*01:02 | HLA-DQB1*05:01 indirect Hy.1B11 T50A
169 Hy.1B11 HLA-DQA1*01:02 | HLA-DQB1*05:01 HLA-DQA1*01:02 | HLA-DQB1*05:01 WT nan D56A 30.8 +/- 2.6 \N \N 0.46 -6.15 0.46 298.15 ENPVVHFFKNIVTPR WT \N \N \N \N 3PL6 \N B CDR2 FQGTGA E 21199956 Biacore 3000 CM5 ENPVVHFFKNIVTPR-HLA-DQA1*01:02 | HLA-DQB1*05:01 indirect Hy.1B11 D54A
170 Hy.1B11 HLA-DQA1*01:02 | HLA-DQB1*05:01 HLA-DQA1*01:02 | HLA-DQB1*05:01 WT nan L97A 110 +/- 6 \N \N 0.13 -5.4 1.21 298.15 ENPVVHFFKNIVTPR WT \N \N \N \N 3PL6 \N B CDR3 ATSALGDTQY E 21199956 Biacore 3000 CM5 ENPVVHFFKNIVTPR-HLA-DQA1*01:02 | HLA-DQB1*05:01 indirect Hy.1B11 L95A
200 BC1 HLA-A*02:01 HLA-A*02:01 WT nan T95Q | S96T |N97A | T98A | G50A | A51I | G52Q | I53T 0.015 \N \N 1426.67 -10.67 -4.3 298.15 SLLMWITQC WT \N \N \N \N 2BNR 1S9W A | A | B | B | B | B | B | B CDR3 | CDR3 | CDR3 | CDR3 | CDR2 | CDR2 | CDR2 | CDR2 \N D | D | E | E | E | E | E | E 22549784 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect BC1 G50A | A51I | G52Q | I53T
316 A6 HLA-A*02:01 HLA-A*02:01 WT nan D99A 10.6 \N \N 0.2 -6.777 0.95 298.15 LLFGYPVYV WT \N \N \N \N 1AO7 \N A CDR3 ASRPGLAGGRPEQY D 23736024 Biacore T100 CM5 A6 D99A direct LLFGYPVYV-HLA-A*02:01
# REMOVE # 319 A6 HLA-A*02:01 HLA-A*02:01 W101A A WT 15.9 \N \N 0.13 -6.537 1.21 298.15 LLFGYPVYV WT \N \N \N \N 1AO7 \N nan \N \N \N 23736024 Biacore T100 CM5 A6 WT direct LLFGYPVYV-HLA-A*02:01 W101A
# REMOVE # 356 A6 HLA-A*02:01 HLA-A*02:01 W101A A R27A 96.7 \N \N 0.03 -5.471 2.08 298.15 LLFGYPVYV WT \N \N \N \N 1AO7 \N A CDR1 DRGSQS D 23736024 Biacore T100 CM5 A6 R27A direct LLFGYPVYV-HLA-A*02:01 W101A
390 A6 HLA-A*02:01 HLA-A*02:01 Q72A A D99A 17.1 \N \N 0.12 -6.495 1.26 298.15 LLFGYPVYV WT \N \N \N \N 1AO7 \N A CDR3 ASRPGLAGGRPEQY D 23736024 Biacore T100 CM5 A6 D99A direct LLFGYPVYV-HLA-A*02:01 Q72A
421 ILAa1b1 HLA-A*02:01 HLA-A*02:01 WT nan H51W | P52E | E53F | Y54E 0.0031+/-0.0012 140000 0.00043 0.65 -10.82 0.26 298.15 ILAKFLHWL WT N/A N/A N/A N/A 4MNQ N/A B | B | B | B CDR2 | CDR2 | CDR2 | CDR2 SIHPEY | SIHPEY | SIHPEY | SIHPEY E | E | E | E 24196962 Biacore T100 CM5 ILAKFLHWL-HLA-A*02:01 indirect ILAa1b1 H51W | P52E | E53F | Y54E
427 ILAa1b1 HLA-A*02:01 HLA-A*02:01 WT nan H51W | P52E | E53F | Y54E 8.4+/-1.1 34000 0.28 0 -6.46 4.94 298.15 ILAAFLHWL K4A N/A N/A N/A N/A 4MNQ N/A B | B | B | B CDR2 | CDR2 | CDR2 | CDR2 SIHPEY | SIHPEY | SIHPEY | SIHPEY E | E | E | E 24196962 Biacore T100 CM5 ILAAFLHWL-HLA-A*02:01 indirect ILAa1b1 H51W | P52E | E53F | Y54E
433 ILAa1b1 HLA-A*02:01 HLA-A*02:01 WT nan H51W | P52E | E53F | Y54E 3.3+/-0.3 15000 0.049 0 -6.97 4.39 298.15 ILAKFAHWL L6A N/A N/A N/A N/A 4MNQ N/A B | B | B | B CDR2 | CDR2 | CDR2 | CDR2 SIHPEY | SIHPEY | SIHPEY | SIHPEY E | E | E | E 24196962 Biacore T100 CM5 ILAKFAHWL-HLA-A*02:01 indirect ILAa1b1 H51W | P52E | E53F | Y54E
458 ANi2.3 HLA-DRA*01:01 | HLA-DRB3*0301 HLA-DRA*01:01 | HLA-DRB3*03:01 WT nan WT 31.7+/-7.3 21500 0.59 1.21 -6.14 -0.11 298.15 WIRVNIPKRI H2W | C5V N/A N/A N/A N/A 4H1L 4H26 nan N/A N/A N/A 23091041 Biacore CM5 ANi2.3 WT direct WIRVNIPKRI-HLA-DRA*01:01 | HLA-DRB3*0301
459 CA5 HLA-B*35:08 HLA-B*35:08 WT nan WT 3.75+/-0.01 508000 0.19 N/A -7.4 N/A 298.15 LPEPLPQGQLTAY WT 4JRX N/A N/A N/A N/A 1ZHL nan N/A N/A N/A 23569211 Biacore 3000 CM5 CA5 WT indirect LPEPLPQGQLTAY-HLA-B*35:08 WT
460 CA5 HLA-B*35:01 HLA-B*35:08 R156L A WT 27.1+/-0.42 344500 0.67N /A -6.23 N/A 298.15 LPEPLPQGQLTAY WT N/A N/A N/A N/A 4JRX 1ZHK nan N/A N/A N/A 23569211 Biacore 3000 CM5 CA5 WT indirect LPEPLPQGQLTAY-HLA-B*35:01 WT
469 SB27 HLA-B*35:08 HLA-B*35:08 I66A A WT 60.8+/-10.0 N/A N/A 0.17 -5.75 1.05 298.15 LPEPLPQGQLTAY WT N/A N/A N/A N/A 2AK4 N/A nan N/A N/A N/A 23569211 Biacore 3000 CM5 SB27 WT indirect LPEPLPQGQLTAY-HLA-B*35:08 I66A
504 TK3 HLA-B*35:08 HLA-B*35:08 WT nan WT 180.5+/-5.5 N/A N/A 0.52 -5.11 0.39 298.15 HPVGQADYFEY E5Q x-ray diffraction 2.5 0.183 0.229 4PRI 4PRE nan N/A N/A N/A 24759101 Biacore 3000 CM5 TK3 WT indirect HPVGQADYFEY-HLA-B*35:08
525 1G4 HLA-A*02:01 HLA-A*02:01 WT nan Q51T | S52P | S53W | T95L | S96L | G97D | S99T | G50A | A51I | G52Q | I53T | V95L 0.000048 570000 0.0000272 "666,666.67" -14.08 -7.94 298.15 SLLMWITQC WT 2P5E x-ray diffraction 1.89 0.181 0.236 2BNR 1S9W A | A | A | A | A | A | A | B | B | B | B | B CDR2 | CDR2 | CDR2 | CDR3 | CDR3 | CDR3 | CDR3 | CDR2 | CDR2 | CDR2 | CDR2 | CDR3 IQSSQRE | IQSSQRE | IQSSQRE | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | SVGAGI | SVGAGI | SVGAGI | SVGAGI | ASSYVGNTGELF D | D | D | D | D | D | D | E | E | E | E | E 17644531 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 Q50T | S51P | S52W | T95L | S96L | G97D | S99T | G49A | A50I | G51Q | I52T | V94L
526 1G4 HLA-A*02:01 HLA-A*02:01 WT nan Q51T | S52P | S53W | G50S | A51V | I53M | T95L | S96L | G97D | S99T | V95L n.d. n.d. 0.000033 N/A \N N/A 298.15 SLLMWITQC WT 2P5W x-ray diffraction 2.2 1.69 0.245 2BNR 1S9W A | A | A | B | B | B | A | A | A | A | B CDR2 | CDR2 | CDR2 | CDR3 | CDR3 | CDR3 | CDR2 | CDR2 | CDR2 | CDR2 | CDR3 IQSSQRE | IQSSQRE | IQSSQRE | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | SVGAGI | SVGAGI | SVGAGI | SVGAGI | ASSYVGNTGELF D | D | D | E | E | E | D | D | D | D | E 17644531 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 Q50T | S51P | S52W | G49S | A50V | I52M | T95L | S96L | G97D | S99T | V94L
527 1G4 HLA-A*02:01 HLA-A*02:01 WT nan Q51P | S52F | S53W | G50S | A51G | I53M 0.0013 181000 0.000237 "24,615.38" -12.12 -5.99 298.15 SLLMWITQC WT N/A N/A N/A N/A 2BNR 1S9W A | A | A | B | B | B CDR2 | CDR2 | CDR2 | CDR2 | CDR2 | CDR2 IQSSQRE | IQSSQRE | IQSSQRE | SVGAGI | SVGAGI | SVGAGI D | D | D | E | E | E 17644531 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 Q51P | S52F | S53W | G49S | A50G | I52M
528 1G4 HLA-A*02:01 HLA-A*02:01 WT nan I53T | T95L | S96L | G97D | S99T | V95L 0.0816 17800 0.00145 392.16 -9.67 -3.53 298.15 SLLMWITQC WT N/A N/A N/A N/A 2BNR 1S9W B | A | A | A | A | B CDR2 | CDR3 | CDR3 | CDR3 | CDR3 SVGAGI | ASSYVGNTGELF | ASSYVGNTGELF | ASSYVGNTGELF | ASSYVGNTGELF E | D | D | D | D | E 17644531 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 I52T | T95L | S96L | G97D | S99T
531 1G4 HLA-A*02:01 HLA-A*02:01 WT nan Y31D | Q51T | S52P | S53W | T95L | S96L | G97D | S99T | G50A | A51I | G52Q | I53T | V95L 18 3320 0.0596 1.78 -6.47 -0.34 298.15 SLLMWITQC WT N/A N/A N/A N/A 2BNR 1S9W A | A | A | A | A | A | A | A | B | B | B | B | B CDR1 | CDR2 | CDR2 | CDR2 | CDR3 | CDR3 | CDR3 | CDR3 | CDR2 | CDR2 | CDR2 | CDR2 | CDR3 DSAIYNL | IQSSQRE | IQSSQRE | IQSSQRE | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | AVRPTSGGSYIPT | SVGAGI | SVGAGI | SVGAGI | SVGAGI | ASSYVGNTGELF D | D | D | D | D | D | D | D | E | E | E | E | E 17644531 Biacore 3000 CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 Y31D | Q50T | S51P | S52W | T95L | S96L | G97D | S99T | G49A | A50I | G51Q | I52T | V94L
553 1G4 HLA-A*02:01 HLA-A*02:01 WT nan G52I 1.1 64000 0.0072 8.45 -8.12 -1.26 298.15 SLLMWITQC WT N/A N/A N/A N/A 2BNR 1S9W B CDR2 SVGAGI E 18424733 Biacore CM5 SLLMWITQC-HLA-A*02:01 indirect 1G4 G52I
663 226 I-Ek I-Ek WT nan WT >500 N/A N/A N/A \N N/A 298.15 ADLIAYLEQATKG K9E 3QIW x-ray diffraction 3.3 0.215 0.367 3QIU nan N/A N/A N/A 21490152 Biacore ADLIAYLEQATKG-I-Ek indirect 226 WT
664 226 I-Ek I-Ek WT nan WT 20.2 N/A N/A 0.02 -6.4 2.45 298.15 ADLIAYLRQATKG K9R N/A N/A N/A N/A 3QIU nan N/A N/A N/A 21490152 Biacore ADLIAYLRQATKG-I-Ek indirect 226 WT
673 2B4 I-Ek I-Ek Q57A A WT 8.6 3920 0.0335 0.64 -6.91 0.28 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk Q61A indirect 2B4 WT
674 2B4 I-Ek I-Ek A61G A WT 24.8 2600 0.0644 0.22 -6.28 0.89 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk A65G indirect 2B4 WT
675 2B4 I-Ek I-Ek A64G A WT 15.4 3200 0.0492 0.36 -6.56 0.61 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk A68G indirect 2B4 WT
676 2B4 I-Ek I-Ek K67A A WT 14.3 2020 0.0286 0.38 -6.61 0.57 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk K71A indirect 2B4 WT
677 2B4 I-Ek I-Ek A68G A WT 22.9 2780 0.0638 0.24 -6.33 0.85 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk A72G indirect 2B4 WT
678 2B4 I-Ek I-Ek E75A A WT 5.5 3950 0.0217 1 -7.17 0 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk E79A indirect 2B4 WT
688 2B4 I-Ek I-Ek K67A | E66A A | B WT 70 640 0.045 0.08 -5.67 1.52 298.15 ANERADLIAYLKQATK WT N/A N/A N/A N/A 3QIB nan N/A N/A N/A 12152083 Biacore N/A ANERADLIAYLKQATK-IEk K71A | E66A indirect 2B4 WT