diff --git a/tdc/benchmark_group/protein_peptide_group.py b/tdc/benchmark_group/protein_peptide_group.py
new file mode 100644
index 00000000..5e003317
--- /dev/null
+++ b/tdc/benchmark_group/protein_peptide_group.py
@@ -0,0 +1,89 @@
+# -*- coding: utf-8 -*-
+# Author: TDC Team
+# License: MIT
+import os
+
+from .base_group import BenchmarkGroup
+
+
+class ProteinPeptideGroup(BenchmarkGroup):
+    """Create Protein-Peptide Group Class object. This is for benchmarking models predicting protein-peptide interactions.
+
+    Args:
+            path (str, optional): the path to store/retrieve the Protein-Peptide group datasets.
+    """
+
+    def __init__(self, path="./data", file_format="csv"):
+        """Create an SCDTI benchmark group class."""
+        # super().__init__(name="SCDTI_Group", path=path)
+        self.name = "ProteinPeptide_Group"
+        self.path = os.path.join(path, self.name)
+        # self.datasets = ["opentargets_dti"]
+        self.dataset_names = ["brown_mdm2_ace2_12ca5"]
+        self.file_format = file_format
+        self.split = None
+
+    def get_train_valid_split(self):
+        """parameters included for compatibility. this benchmark has a fixed train/test split."""
+        import pandas as pd
+        from sklearn.model_selection import train_test_split
+        from ..multi_pred.proteinpeptide import ProteinPeptide as DataLoader
+        if self.split is None:
+            dl = DataLoader(name="brown_mdm2_ace2_12ca5")
+            df = dl.get_data()
+            for idx, e in enumerate(df["Y"]):
+                if e != "Putative binder":
+                    df["Y"][idx] = "1"
+                else:
+                    df["Y"][idx] = "0"
+            # raise Exception("unique", )
+            # Split the data while stratifying
+            X_train, X_test, y_train, y_test = train_test_split(
+                df.drop('Y', axis=1),  # features
+                df['Y'],  # labels
+                test_size=0.9,  # 90% of the data goes to the test set
+                random_state=42,  # for reproducibility
+                stratify=df[
+                    'Y']  # stratify by the label column to ensure even distribution
+            )
+            self.split = {}
+            self.split["train"] = (X_train, y_train)
+            self.split["test"] = (X_test, y_test)
+            self.split["dev"] = []
+
+        return self.split["train"], self.split["dev"]
+
+    def get_test(self):
+        from ..multi_pred.proteinpeptide import ProteinPeptide as DataLoader
+        if self.split is None:
+            self.get_train_valid_split()
+        return self.split["test"]
+
+    def evaluate(self, y_pred):
+        from sklearn.metrics import precision_score, recall_score, accuracy_score, f1_score, roc_auc_score
+        y_true = self.get_test()[1]
+        # Calculate metrics
+        precision = precision_score(y_true, y_pred, pos_label="1")
+        recall = recall_score(y_true, y_pred, pos_label="1")
+        accuracy = accuracy_score(y_true, y_pred)
+        f1 = f1_score(y_true, y_pred, pos_label="1")
+        auc = roc_auc_score(y_true, y_pred)
+        return [precision, recall, accuracy, f1]
+
+    def evaluate_many(self, preds):
+        from numpy import mean, std
+        if len(preds) < 5:
+            raise Exception(
+                "Run your model on at least 5 seeds to compare results and provide your outputs in preds."
+            )
+        out = dict()
+        preds = [self.evaluate(p) for p in preds]
+        out["precision"] = (mean([x[0] for x in preds]),
+                            std([x[0] for x in preds]))
+        out["recall"] = (mean([x[1] for x in preds]), std([x[1] for x in preds
+                                                          ]))
+        out["accuracy"] = (mean([x[2] for x in preds]),
+                           std([x[2] for x in preds]))
+        out["f1"] = (mean([x[3] for x in preds]), std([x[3] for x in preds]))
+        # out["auc"] = (mean([x[4] for x in preds]), std([x[4] for x in preds]))
+        return out
diff --git a/tdc/test/test_benchmark.py b/tdc/test/test_benchmark.py
index fe981c22..5266baeb 100644
--- a/tdc/test/test_benchmark.py
+++ b/tdc/test/test_benchmark.py
@@ -116,6 +116,33 @@ def test_counterfactual(self):
         assert not group_gene.is_drug
         assert set(group_gene.dataset_names) == set(scperturb_gene_datasets)
 
+    def test_proteinpeptide(self):
+        from tdc.benchmark_group.protein_peptide_group import ProteinPeptideGroup
+        from tdc.multi_pred.proteinpeptide import ProteinPeptide
+        from sklearn.model_selection import train_test_split
+        group = ProteinPeptideGroup()
+        test = group.get_test()
+        assert test is not None and len(test) > 0
+        dl = ProteinPeptide(name="brown_mdm2_ace2_12ca5")
+        df = dl.get_data()
+        for idx, e in enumerate(df["Y"]):
+            if e != "Putative binder":
+                df["Y"][idx] = "1"
+            else:
+                df["Y"][idx] = "0"
+        # raise Exception("unique", )
+        # Split the data while stratifying
+        _, _, _, y_test = train_test_split(
+            df.drop('Y', axis=1),  # features
+            df['Y'],  # labels
+            test_size=0.9,  # 90% of the data goes to the test set
+            random_state=42,  # for reproducibility
+            stratify=df[
+                'Y']  # stratify by the label column to ensure even distribution
+        )
+        res = group.evaluate(y_test)
+        assert res[-1] == 1 and res[-2] == 1, res
+
 
 if __name__ == "__main__":
     unittest.main()