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Pierre Lindenbaum edited this page Apr 21, 2016 · 7 revisions

##Motivation

Prepare R Script from VCF file.

##Compilation

Requirements / Dependencies

Download and Compile

$ git clone "https://github.com/lindenb/jvarkit.git"
$ cd jvarkit
$ make vcfburdenrscriptv

by default, the libraries are not included in the jar file, so you shouldn't move them (https://github.com/lindenb/jvarkit/issues/15#issuecomment-140099011 ). You can create a bigger but standalone executable jar by addinging standalone=yes on the command line:

$ git clone "https://github.com/lindenb/jvarkit.git"
$ cd jvarkit
$ make vcfburdenrscriptv standalone=yes

The required libraries will be downloaded and installed in the dist directory.

edit 'local.mk' (optional)

The a file local.mk can be created edited to override/add some paths.

For example it can be used to set the HTTP proxy:

http.proxy.host=your.host.com
http.proxy.port=124567

##Synopsis

$ java -jar dist/vcfburdenrscriptv.jar  [options] (stdin|file.vcf|file.vcf.gz) 

Options

  • -o|--output (OUTPUT-FILE) Output file. Default:stdout
  • -if|--ignorefilter accept variants having a FILTER column. Default is ignore variants with a FILTER column Default value : "false".
  • -h|--help print help
  • -version|--version show version and exit

##Source Code

Main code is: https://github.com/lindenb/jvarkit/blob/master/src/main/java/com/github/lindenb/jvarkit/tools/burden/VcfBurdenRscriptV.java

Output

INFO column

  • BurdenF1Fisher : Fisher test

FILTER column

  • BurdenF1Fisher :Fisher test doesn't meet user's requirements

see also

Contribute

License

The project is licensed under the MIT license.

Citing

Should you cite vcfburdenrscriptv ? https://github.com/mr-c/shouldacite/blob/master/should-I-cite-this-software.md

The current reference is:

http://dx.doi.org/10.6084/m9.figshare.1425030

Lindenbaum, Pierre (2015): JVarkit: java-based utilities for Bioinformatics. figshare. http://dx.doi.org/10.6084/m9.figshare.1425030

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