diff --git a/jaxlib/mlir/_mlir_libs/BUILD.bazel b/jaxlib/mlir/_mlir_libs/BUILD.bazel
index 511a2310b3b4..817c23a11636 100644
--- a/jaxlib/mlir/_mlir_libs/BUILD.bazel
+++ b/jaxlib/mlir/_mlir_libs/BUILD.bazel
@@ -70,8 +70,8 @@ py_extension(
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPIGPUHeaders",
         "@llvm-project//mlir:CAPIIRHeaders",
-        "@llvm-project//mlir:MLIRBindingsPythonHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )
 
@@ -85,7 +85,8 @@ py_extension(
     deps = [
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPIGPUHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )
 
@@ -100,8 +101,8 @@ py_extension(
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPIIRHeaders",
         "@llvm-project//mlir:CAPINVGPUHeaders",
-        "@llvm-project//mlir:MLIRBindingsPythonHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )
 
@@ -116,8 +117,8 @@ py_extension(
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPIIRHeaders",
         "@llvm-project//mlir:CAPILLVMHeaders",
-        "@llvm-project//mlir:MLIRBindingsPythonHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )
 
@@ -131,8 +132,8 @@ py_extension(
     deps = [
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPISparseTensorHeaders",
-        "@llvm-project//mlir:MLIRBindingsPythonHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )
 
@@ -146,7 +147,8 @@ py_extension(
     deps = [
         ":jaxlib_mlir_capi_shared_library",
         "@llvm-project//mlir:CAPISparseTensorHeaders",
-        "@pybind11",
+        "@llvm-project//mlir:MLIRBindingsPythonNanobindHeaders",
+        "@nanobind",
     ],
 )