diff --git a/easybuild/main.py b/easybuild/main.py
index 42bd83dff5..451152f322 100644
--- a/easybuild/main.py
+++ b/easybuild/main.py
@@ -83,6 +83,8 @@
 from easybuild.tools.repository.repository import init_repository
 from easybuild.tools.systemtools import check_easybuild_deps
 from easybuild.tools.testing import create_test_report, overall_test_report, regtest, session_state
+from easybuild.tools.version import EASYBLOCKS_VERSION, FRAMEWORK_VERSION, UNKNOWN_EASYBLOCKS_VERSION
+from easybuild.tools.version import different_major_versions
 
 
 _log = None
@@ -618,6 +620,15 @@ def main(args=None, logfile=None, do_build=None, testing=False, modtool=None, pr
     (build_specs, _log, logfile, robot_path, search_query, eb_tmpdir, try_to_generate,
      from_pr_list, tweaked_ecs_paths) = cfg_settings
 
+    # compare running Framework and EasyBlocks versions
+    if EASYBLOCKS_VERSION == UNKNOWN_EASYBLOCKS_VERSION:
+        # most likely reason is running framework unit tests with no easyblocks installation
+        # so log a warning, to avoid test related issues
+        _log.warning("Unable to determine EasyBlocks version, so we'll assume it is not different from Framework")
+    elif different_major_versions(FRAMEWORK_VERSION, EASYBLOCKS_VERSION):
+        raise EasyBuildError("Framework (%s) and EasyBlock (%s) major versions are different." % (FRAMEWORK_VERSION,
+                                                                                                  EASYBLOCKS_VERSION))
+
     # load hook implementations (if any)
     hooks = load_hooks(options.hooks)
 
diff --git a/easybuild/tools/github.py b/easybuild/tools/github.py
index ae9b78b5ed..6a8401d7ae 100644
--- a/easybuild/tools/github.py
+++ b/easybuild/tools/github.py
@@ -60,6 +60,7 @@
 from easybuild.tools.py2vs3 import HTTPError, URLError, ascii_letters, urlopen
 from easybuild.tools.systemtools import UNKNOWN, get_tool_version
 from easybuild.tools.utilities import nub, only_if_module_is_available
+from easybuild.tools.version import FRAMEWORK_VERSION, different_major_versions
 
 
 _log = fancylogger.getLogger('github', fname=False)
@@ -587,9 +588,39 @@ def fetch_files_from_pr(pr, path=None, github_user=None, github_account=None, gi
         else:
             raise EasyBuildError("Couldn't find path to patched file %s", full_path)
 
+    if github_repo == GITHUB_EASYCONFIGS_REPO:
+        ver = _get_version_for_repo(os.path.join(final_path, 'setup.py'))
+    elif github_repo == GITHUB_EASYBLOCKS_REPO:
+        ver = _get_version_for_repo(os.path.join(final_path, 'easybuild', 'easyblocks', '__init__.py'))
+
+    if different_major_versions(FRAMEWORK_VERSION, ver):
+        raise EasyBuildError("Framework (%s) is a different major version than used in %s/%s PR #%s (%s)",
+                             FRAMEWORK_VERSION, github_account, github_repo, pr, ver)
+
     return files
 
 
+def _get_version_for_repo(filename):
+    """Extract version from filename."""
+    _log.debug("Extract version from %s" % filename)
+
+    try:
+        ver_line = ""
+        with open(filename) as f:
+            for line in f.readlines():
+                if line.startswith("VERSION "):
+                    ver_line = line
+                    break
+
+        # version can be a string or LooseVersion
+        res = re.search(r"""^VERSION = .*['"](.*)['"].?$""", ver_line)
+
+        _log.debug("PR target version is %s" % res.group(1))
+        return res.group(1)
+    except Exception:
+        raise EasyBuildError("Couldn't determine version of PR from %s" % filename)
+
+
 def fetch_easyblocks_from_pr(pr, path=None, github_user=None):
     """Fetch patched easyblocks for a particular PR."""
     return fetch_files_from_pr(pr, path, github_user, github_repo=GITHUB_EASYBLOCKS_REPO)
diff --git a/easybuild/tools/version.py b/easybuild/tools/version.py
index c01c8fc5c3..e29f6f0b29 100644
--- a/easybuild/tools/version.py
+++ b/easybuild/tools/version.py
@@ -47,6 +47,7 @@
 # This causes problems further up the dependency chain...
 VERSION = LooseVersion('4.9.2.dev0')
 UNKNOWN = 'UNKNOWN'
+UNKNOWN_EASYBLOCKS_VERSION = '0.0.UNKNOWN.EASYBLOCKS'
 
 
 def get_git_revision():
@@ -87,7 +88,7 @@ def get_git_revision():
 try:
     from easybuild.easyblocks import VERBOSE_VERSION as EASYBLOCKS_VERSION
 except Exception:
-    EASYBLOCKS_VERSION = '0.0.UNKNOWN.EASYBLOCKS'  # make sure it is smaller then anything
+    EASYBLOCKS_VERSION = UNKNOWN_EASYBLOCKS_VERSION  # make sure it is smaller then anything
 
 
 def this_is_easybuild():
@@ -103,3 +104,14 @@ def this_is_easybuild():
         msg = msg.encode('ascii')
 
     return msg
+
+
+def different_major_versions(v1, v2):
+    """Compare major versions"""
+    # Deal with version instances being either strings or LooseVersion
+    if isinstance(v1, str):
+        v1 = LooseVersion(v1)
+    if isinstance(v2, str):
+        v2 = LooseVersion(v2)
+
+    return v1.version[0] != v2.version[0]